The building in which Hermitage Amsterdam is currently housed was for 324 years a home for the elderly. When at the close of the twentieth century it became apparent that Amstelhof care facility no longer met contemporary requirements it was decided to find a new use for the building. Since June 2009 the site has been home to Hermitage Amsterdam.

Following its complete renovation, three architectural bureaus combined to turn Amstelhof into a modern museum: Hans van Heeswijk (building), Merkx+Girod (interior) and Michael van Gessel (grounds).